Nafis Rizqi Nurhandokoputra, . (2026) EFEKTIVITAS TERAPI LABA DAN LAMA DENGAN ATAU TANPA KORTIKOSTEROID TERHADAP NILAI pCO₂ PASIEN PPOK LAKI-LAKI DI RSPAD GATOT SOEBROTO TAHUN 2024. Skripsi thesis, Universitas Pembangunan Nasional Veteran Jakarta.
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Abstract
Chronic Obstructive Pulmonary Disease (COPD) is a lung disease characterized by heterogeneous and progressive features, marked by persistent respiratory symptoms such as shortness of breath, coughing, and mucus production. This condition is caused by airway obstruction and/or alveolar damage, leading to persistent airflow limitation that tends to worsen over time. This study aims to determine the effectiveness of long-acting bronchodilator therapy, namely Long-Acting Beta Agonists (LABA) and Long-Acting Muscarinic Antagonists (LAMA), with or without corticosteroids, on partial pressure of carbon dioxide (pCO₂) levels in COPD patients. This study is an observational analysis that collected data retrospectively using a retrospective cohort design based on medical records of COPD patients. Analysis was conducted on changes in pCO₂ levels before and after therapy administration. The results showed that LABA and LAMA therapy was effective in lowering pCO₂ levels, with a mean ± SD decrease of 5.54 ± 2.30 mmHg. Similarly, combined LABA, LAMA, and corticosteroid therapy was effective in lowering pCO₂ levels, with a mean ± SD decrease of 7.72 ± 3.05 mmHg. The administration of LABA and LAMA therapy, with or without the addition of corticosteroids, was effective in improving pCO₂ levels in COPD patients.
| Item Type: | Thesis (Skripsi) |
|---|---|
| Additional Information: | [No.Panggil: 2210212041] [Pembimbing: Annisa Farida Muti] [Penguji 1: Dhigna Luthfiyani Citra Pradana] [Penguji 2: Nurfitri Bustamam] |
| Uncontrolled Keywords: | COPD, Corticosteroids, LABA, LAMA, pCO₂ |
| Subjects: | R Medicine > R Medicine (General) R Medicine > RM Therapeutics. Pharmacology R Medicine > RS Pharmacy and materia medica |
| Divisions: | Fakultas Kedokteran > Program Studi Farmasi (S1) |
| Depositing User: | NAFIS RIZQI NURHANDOKOPUTRA |
| Date Deposited: | 04 Sep 2026 03:06 |
| Last Modified: | 04 Sep 2026 03:06 |
| URI: | http://repository.upnvj.ac.id/id/eprint/50439 |
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