POTENSI ANTIOKSIDAN EKSTRAK ETANOL BUNGA KRISAN (Chrysanthemum morifolium) TERHADAP KADAR MALONDIALDEHYDE PANKREAS PADA TIKUS MODEL HIPERKOLESTEROLEMIA DIABETES

Hanny Kartiko Rahayu, . (2026) POTENSI ANTIOKSIDAN EKSTRAK ETANOL BUNGA KRISAN (Chrysanthemum morifolium) TERHADAP KADAR MALONDIALDEHYDE PANKREAS PADA TIKUS MODEL HIPERKOLESTEROLEMIA DIABETES. Skripsi thesis, Universitas Pembangunan Nasional Veteran Jakarta.

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Abstract

Objective Type 2 diabetes mellitus is frequently accompanied by hypercholesterolemia, which increases oxidative stress and contributes to pancreatic tissue damage. Oxidative stress induces lipid peroxidation, producing malondialdehyde (MDA) as a biomarker of cellular damage. Chrysanthemum (Chrysanthemum morifolium) flowers contain bioactive compounds with antioxidant properties that may reduce oxidative stress. This study aimed to evaluate the effect of ethanol extract of chrysanthemum flowers on pancreatic malondialdehyde (MDA) levels in hypercholesterolemic diabetic male Wistar rats. Method This study was an experimental laboratory research with a post-test only control group design. Male Wistar rats were divided into a normal group, negative control, positive control, and treatment groups receiving ethanol extract of chrysanthemum flowers at doses of 75, 150, and 300 mg/kg body weight. Diabetes and hypercholesterolemia were induced prior to treatment. After the treatment period, the rats were sacrificed and pancreatic tissues were collected to measure MDA levels using spectrophotometric methods. Statistical analysis was performed to compare MDA levels among groups. Results Administration of ethanol extract of chrysanthemum flowers significantly reduced pancreatic MDA levels compared to the negative control group. The greatest reduction in MDA levels was observed in the group receiving a dose of 300 mg/kg body weight, indicating the strongest antioxidant effect. Conclusion Ethanol extract of chrysanthemum flowers (Chrysanthemum morifolium) demonstrates antioxidant potential by reducing pancreatic malondialdehyde (MDA) levels in hypercholesterolemic diabetic male Wistar rats in a dose-dependent manner. Keywords : Chrysanthemum morifolium, diabetes mellitus, hypercholesterolemia, malondialdehyde, oxidative stress.

Item Type: Thesis (Skripsi)
Additional Information: [No.Panggil : 2210211202] [Pembimbing 1 : Retno Yulianti] [Pembimbing 2 : Tri Faranita] [Penguji : Ima Maria]
Uncontrolled Keywords: Chrysanthemum morifolium, diabetes mellitus, hypercholesterolemia, malondialdehyde, oxidative stress.
Subjects: R Medicine > RB Pathology
Divisions: Fakultas Kedokteran > Program Studi Kedokteran (S1)
Depositing User: HANNY KARTIKO RAHAYU
Date Deposited: 12 May 2026 01:53
Last Modified: 12 May 2026 01:53
URI: http://repository.upnvj.ac.id/id/eprint/42268

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