Muhammad Alghaniy Fatahillah Mubarok, . (2026) POTENSI EKSTRAK BUAH KELOR (Moringa oleifera fruits) TERHADAP AKTIVITAS SPESIFIK ENZIM MnSOD (Manganese superoxide dismutase) PADA TIKUS GALUR SPRAGUE DAWLEY (Rattus norvegicus) MODEL OBESITAS. Skripsi thesis, Universitas Pembangunan Nasional Veteran Jakarta.
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Abstract
Purpose Metabolic dysfunction-associated fatty liver disease (MAFLD) is a condition where fat accumulate in the liver due to metabolic dysfunction. Obesity could trigger MAFLD because it induces excessive oxidative stress in the liver. Moringa fruits have polyphenol contents that could increase the specific activity of manganese superoxide dismutase enzyme (MnSOD) in the liver, thus reducing liver’s oxidative stress. This research is aimed at researching Moringa fruit’s extract potential to increase specific MnSOD enzyme activity in obese Sprague Dawley strain white rats (R. norvegicus). Methodology This research is pure experimental with a posttest control group design consisting of 30 samples of Sprague Dawley strain white rat. There will be 5 different groups, with 3 control groups and 2 treatment groups that will be given moringa fruits extract with 500 mg/KgBW once a day and twice a day doses. Specific activity of MnSOD enzyme in the liver will be examined with RAT SOD2 ELISA kit then analyzed with One Way Annova continued with Post Hoc Tukey. Result Ethanol 96% maceration of moringa fruits extract can increase specific activity of MnSOD enzyme in the liver with 500 mg/KgBW once a day and twice a day doses. Higher dosage also shows higher increase in specific activity of MnSOD enzyme in the liver Conclusion Moringa fruits extract has potential benefits as a herb for increasing specific activity of MnSOD enzyme in the liver and repair oxidative stress caused by the accumulation of lipids.
| Item Type: | Thesis (Skripsi) |
|---|---|
| Additional Information: | [No.Panggil: 2210211061] [Penguji: Retno Yulianti] [Pembimbing 1: Maria Selvester Thadeus] [Pembimbing 2: Marlina Dewiastuti] |
| Uncontrolled Keywords: | Moringa fruits, MnSOD enzyme, MAFLD, Antioxidant |
| Subjects: | R Medicine > RS Pharmacy and materia medica R Medicine > RZ Other systems of medicine |
| Divisions: | Fakultas Kedokteran > Program Studi Kedokteran (S1) |
| Depositing User: | MUHAMMAD ALGHANIY FATAHILLAH MUBAROK |
| Date Deposited: | 07 May 2026 03:08 |
| Last Modified: | 07 May 2026 03:08 |
| URI: | http://repository.upnvj.ac.id/id/eprint/41932 |
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