EFEK EKSTRAK BONGGOL NANAS (Ananas comosus (L.) Merr.) TERHADAP RESISTENSI INSULIN DAN FUNGSI SEL β PANKREAS PADA TIKUS WISTAR (Rattus norvegicus) MODEL DIABETES ALOKSAN MELALUI ANALISIS HOMA

Muhammad Azka Azkiya Arif, . (2026) EFEK EKSTRAK BONGGOL NANAS (Ananas comosus (L.) Merr.) TERHADAP RESISTENSI INSULIN DAN FUNGSI SEL β PANKREAS PADA TIKUS WISTAR (Rattus norvegicus) MODEL DIABETES ALOKSAN MELALUI ANALISIS HOMA. Skripsi thesis, Universitas Pembangunan Nasional Veteran Jakarta.

[img] Text
ABSTRAK.pdf
Download (155kB)
[img] Text
AWAL.pdf
Download (4MB)
[img] Text
BAB 1.pdf
Restricted to Repository UPNVJ Only
Download (202kB)
[img] Text
BAB 2.pdf
Restricted to Repository UPNVJ Only
Download (5MB)
[img] Text
BAB 3.pdf
Restricted to Repository UPNVJ Only
Download (290kB)
[img] Text
BAB 4.pdf
Restricted to Repository UPNVJ Only
Download (382kB)
[img] Text
BAB 5.pdf
Download (189kB)
[img] Text
DAFTAR PUSTAKA.pdf
Download (242kB)
[img] Text
RIWAYAT HIDUP.pdf
Restricted to Repository UPNVJ Only
Download (297kB)
[img] Text
LAMPIRAN.pdf
Restricted to Repository UPNVJ Only
Download (16MB)
[img] Text
HASIL PLAGIARISME.pdf
Restricted to Repository staff only
Download (20MB)
[img] Text
ARTIKEL KI.pdf
Restricted to Repository staff only
Download (278kB)

Abstract

Objective Diabetes mellitus is associated with insulin resistance and pancreatic β-cell dysfunction. Pineapple core (Ananas comosus (L.) Merr.) contains bioactive compounds with potential effects on glucose and insulin metabolism. This study aimed to evaluate the effect of pineapple core extract on insulin sensitivity in alloxan-induced diabetic Wistar rats using HOMA-IR and HOMA-β parameters. Method This was an experimental laboratory study with a post-test only control group design. Male Wistar rats were induced with alloxan and divided into control and treatment groups receiving graded doses of pineapple core extract. Fasting blood glucose was measured using a glucometer, while plasma insulin levels were determined by ELISA. Insulin sensitivity and β-cell function were assessed using HOMA-IR and HOMA-β. Result There was a significant difference in HOMA-IR and HOMA-β between the negative control group and the highest-dose treatment group (treatment 3) (p = 0.034). Conclusion Pineapple core extract (Ananas comosus (L.) Merr.) at a certain dose may improve pancreatic β-cell function and insulin sensitivity based on HOMA-IR and HOMA-β parameters in alloxan-induced diabetic Wistar rats.

Item Type: Thesis (Skripsi)
Additional Information: [No.Panggil: 2210211126] [Pembimbing 1: Yosha Putri Wahyuni] [Pembimbing 2: Isniani Ramadhani Sekar Prabarini] [Penguji: Cut Fauziah]
Uncontrolled Keywords: Pineapple core, Diabetes mellitus, Extract, HOMA, Insulin.
Subjects: Q Science > QH Natural history > QH301 Biology
R Medicine > R Medicine (General)
Divisions: Fakultas Kedokteran > Program Studi Kedokteran (S1)
Depositing User: MUHAMMAD AZKA AZKIYA ARIF
Date Deposited: 30 Mar 2026 09:59
Last Modified: 31 Mar 2026 01:33
URI: http://repository.upnvj.ac.id/id/eprint/41802

Actions (login required)

View Item View Item