EFEKTIVITAS EKSTRAK RUMPUT MUTIARA (Hedyotis corymbosa (L.) Lam.) DENGAN METODE ULTRASONIC ASSISTED EXTRACTION SEBAGAI ANTIFUNGI TERHADAP PERTUMBUHAN JAMUR Malassezia furfur SECARA IN VITRO

Aufa Saniyyah Abdaah Merdeka Sari, . (2025) EFEKTIVITAS EKSTRAK RUMPUT MUTIARA (Hedyotis corymbosa (L.) Lam.) DENGAN METODE ULTRASONIC ASSISTED EXTRACTION SEBAGAI ANTIFUNGI TERHADAP PERTUMBUHAN JAMUR Malassezia furfur SECARA IN VITRO. Skripsi thesis, Universitas Pembangunan Nasional Veteran Jakarta.

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Abstract

The incidence of superficial fungal skin infections in Indonesia continues to increase, one of which is caused by Malassezia furfur, the etiological agent of tinea versicolor. Treatment using synthetic antifungal agents often results in adverse effects and may contribute to antifungal resistance. Pearl grass (Hedyotis corymbosa) extract may serve as an alternative antifungal treatment due to its secondary metabolites, including saponins, alkaloids, flavonoids, tannins, and triterpenoids. This study aimed to determine the effectiveness of H. corymbosa extract obtained using the Ultrasonic Assisted Extraction (UAE) method against the in vitro growth of M. furfur. This study employed a post-test only control group experimental design using the well diffusion method. Inhibition zone diameters on Sabouraud Dextrose Agar were measured at extract concentrations of 10%, 15%, 20%, 25%, and 30% after 24 and 48 hours of incubation to assess antifungal effectiveness. Data were analyzed using the Kruskal–Wallis test followed by the Mann–Whitney post hoc test. The Kruskal–Wallis analysis revealed significant differences in inhibition zone diameters among the treatment groups (p < 0.05). The results indicate that H. corymbosa extract is effective in inhibiting the growth of Malassezia furfur.

Item Type: Thesis (Skripsi)
Additional Information: [No.Panggil: 2210211036] [Pembimbing 1: Yuni Setyaningsih] [Pembimbing 2: Citra Ayu Aprilia] [Penguji: Fajriati Zulfa]
Uncontrolled Keywords: Antifungal, well diffusion, Hedyotis corymbosa, Malassezia furfur, UAE
Subjects: Q Science > QR Microbiology
Divisions: Fakultas Kedokteran > Program Studi Kedokteran (S1)
Depositing User: AUFA SANIYYAH ABDAAH MERDEKA SARI
Date Deposited: 20 Apr 2026 04:38
Last Modified: 20 Apr 2026 04:38
URI: http://repository.upnvj.ac.id/id/eprint/41701

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