PENGARUH TERAPI SEL NATURAL KILLER (NK) TERHADAP VIABILITAS DAN APOPTOSIS PADA GALUR SEL KANKER KOLON HT-29 SECARA IN VITRO

Amanda Seraphine Yuswanto, . (2026) PENGARUH TERAPI SEL NATURAL KILLER (NK) TERHADAP VIABILITAS DAN APOPTOSIS PADA GALUR SEL KANKER KOLON HT-29 SECARA IN VITRO. Skripsi thesis, Universitas Pembangunan Nasional Veteran Jakarta.

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Abstract

Background: Colon cancer is one of the leading causes of cancer-related mortality worldwide. One alternative therapeutic approach involves the use of immune cells. Natural killer (NK) cells have been shown to be effective in targeting colon cancer cells. The effectiveness of NK cells against colon cancer was evaluated in vitro using the HT-29 colon cancer cell line. Method: This study was a true experimental study with a control group design. The collected data were analyzed using SPSS software. Statistical analyses included one-way analysis of variance (one-way ANOVA). Results were considered statistically significant at a p-value < 0.05. Results: A decrease in cell viability and an increase in apoptosis of HT-29 colon cancer cell line were observed with increasing E:T ratios. Conclusion: NK cell therapy was most effective in reducing cell viability and increasing apoptosis of HT-29 colon cancer cell line with E:T ratio of 50:1.

Item Type: Thesis (Skripsi)
Additional Information: [No. Panggil: 2210211203] [Pembimbing 1: Karina] [Pembimbing 2: Tri Faranita] [Penguji: Maulidya Ayudika Dandanah]
Uncontrolled Keywords: Immunotherapy, natural killer cells, viability, apoptosis, HT-29 colon cancer cell line.
Subjects: R Medicine > R Medicine (General)
Divisions: Fakultas Kedokteran > Program Studi Kedokteran (S1)
Depositing User: AMANDA SERAPHINE YUSWANTO
Date Deposited: 01 May 2026 03:18
Last Modified: 07 May 2026 01:35
URI: http://repository.upnvj.ac.id/id/eprint/41563

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