Alissa Aurelia, . (2026) EVALUASI AKTIVITAS HEPATOPROTEKTIF EKSTRAK BUAH KELOR (Moringa oleifera fruits) PADA GAMBARAN HISTOPATOLOGI HATI TIKUS (Rattus norvegicus) GALUR Sprague Dawley MODEL OBESITAS. Skripsi thesis, Universitas Pembangunan Nasional Veteran Jakarta.
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Abstract
As a primary contributor to the global health burden, Non- alcoholic fatty liver disease (NAFLD) has emerged as one of the fastest-rising metabolic disorders worldwide, largely driven by the rising obesity rates, high-calorie dietary pattern, and increasingly sedentary lifestyle. High-fat diets promotes the deposition of free fatty acid within the hepatic tissue, initiating oxidative stress-mediated hepatocellular injury. Moringa oleifera fruits are abundant in bioactive constituents, particularly flavonoids, polyphenols, and alkaloids, which exhibit notable hepatoprotective properties.This study is a true experimental design with a post-test-only control group approach with 30 male Sprague Dawley strain rats (Rattus norvegicus). The rats will be random allocated into five groups, including three control groups and two intervention groups subjected to Moringa oleifera fruit extract at a dosage of 500 mg/KgBW administered once or twice a day. The evaluation of histopathological findings will be analyzed using One Way ANOVA, followed by Tukey’s Post-Hoc. Macerated Moringa oleifera fruit extract demonstrated a reduction in steatosis severity, as assessed by the Non-Alcoholic Fatty Liver Disease Activiy Score (NAS). The most prominent effect was observed at a dosage of 500 mg/KgBW administered twice a day, followed by vitamin C and the one a day 500 mg/KgBW regimen. The antioxidant constituents of Moringa oleifera fruit extract exhibit hepatoprotective activity through the reduction of oxidative stress, inhibition of lipid peroxidation, and reduction of hepatocyte structural degeneration, as evidenced by histopathological findings in Sprague Dawley rats.
| Item Type: | Thesis (Skripsi) |
|---|---|
| Additional Information: | [No. Panggil: 2210211077] [Pembimbing 1: Maria Selvester Thadeus] [Pembimbing 2: Meiskha Bahar] [Penguji: Niniek Hardini] |
| Uncontrolled Keywords: | Ballooning; Histopathology; Lobule Inflammation; Moringa oleifera fruit; Steatosis |
| Subjects: | R Medicine > RB Pathology R Medicine > RS Pharmacy and materia medica |
| Divisions: | Fakultas Kedokteran > Program Studi Kedokteran (S1) |
| Depositing User: | ALISSA AURELIA |
| Date Deposited: | 04 May 2026 03:51 |
| Last Modified: | 04 May 2026 03:51 |
| URI: | http://repository.upnvj.ac.id/id/eprint/41463 |
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