PENGARUH PEMBERIAN EKSTRAK BUAH KELOR (Moringa oleifera fruits) TERHADAP KADAR LOW-DENSITY LIPOPROTEIN (LDL) PADA TIKUS MODEL OBESITAS

Djuwita Dwi Annisa, . (2026) PENGARUH PEMBERIAN EKSTRAK BUAH KELOR (Moringa oleifera fruits) TERHADAP KADAR LOW-DENSITY LIPOPROTEIN (LDL) PADA TIKUS MODEL OBESITAS. Skripsi thesis, Universitas Pembangunan Nasional Veteran Jakarta.

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Abstract

Obesity is characterized by excessive fat accumulation and is frequently accompanied by dyslipidemia, which is marked by increased low-density lipoprotein (LDL) and triglyceride levels, presenting significant cardiovascular risks. Conventional statin-based therapies for dyslipidemia management have associated adverse effects, prompting exploration of natural therapeutic alternatives. This research investigated the efficacy of Moringa oleifera fruit extract in reducing LDL concentrations in obese rats. A true experimental design with post-test only control group methodology was employed, utilizing 30 male Sprague Dawley rats distributed across five treatment groups: K1 (normal control), K2 (negative control with diet-induced obesity), K3 (positive control receiving vitamin C), K4 (extract dose 500 mg/kgBW once daily), and K5 (extract dose 500 mg/kgBW twice daily). Following a 30-day high-fat, high-protein diet induction period, rats received assigned treatments for 14 days. Serum LDL levels were quantified using the CHOD-PAP method with ELISA reader analysis. One-Way ANOVA statistical analysis was performed at 5% significance level (α = 0.05). Results indicated that Moringa oleifera fruit extract effectively reduced LDL levels in obese model rats, with dose and administration frequency significantly influencing therapeutic outcomes. The bioactive compounds identified in the extract, including flavonoids, phenolic substances, and polyphenols, demonstrated capacity to suppress LDL oxidation and attenuate cholesterol synthesis via HMG CoA reductase inhibition. This study establishes Moringa oleifera fruit extract as a promising, natural-based therapeutic intervention for managing dyslipidemia and reducing cardiovascular risk in obese populations.

Item Type: Thesis (Skripsi)
Additional Information: [No.Panggil: 2210211175] [Pembimbing: Tiwuk Susantiningsih] [Penguji 1: Desi Purwaningsih] [Penguji 2: Nasihin Saud Irsyad]
Uncontrolled Keywords: Moringa oleifera fruit extract, dyslipidemia, low-density lipoprotein, obesity management, natural antioxidants, lipid metabolism
Subjects: R Medicine > R Medicine (General)
Divisions: Fakultas Kedokteran > Program Studi Kedokteran (S1)
Depositing User: DJUWITA DWI ANNISA
Date Deposited: 04 May 2026 04:18
Last Modified: 04 May 2026 04:18
URI: http://repository.upnvj.ac.id/id/eprint/41081

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