Gherriandi Raja Buana, . (2025) PERBANDINGAN LUAS INFARK OTAK PADA MODEL MIDDLE CEREBRAL ARTERY OCCLUSION PERMANEN DAN TRANSIEN. Skripsi thesis, Universitas Pembangunan Nasional Veteran Jakarta.
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Abstract
Ischemic stroke is a leading cause of disability and death worldwide, with middle cerebral artery occlusion (MCAO) serving as a widely used experimental model to study the pathophysiology of brain injury. This study aims to compare the extent of brain infarction between permanent (pMCAO) and transient (tMCAO) MCAO models, and to evaluate the effectiveness of pMCAO in representing clinical ischemic stroke. Experimental animals were divided into pMCAO and tMCAO groups, then infarct size was analyzed using Triphenyltetrazolium Chloride (TTC) and neuron viability by Hematoxylin-Eosin (HE) staining. The results showed that the pMCAO model produced larger and more consistent infarcts than the tMCAO model, particularly at 24 hours post-occlusion. These findings support the use of pMCAO as a more optimal model for representing non-reperfused ischemic stroke and provide a reference for selecting animal models in experimental stroke research.
| Item Type: | Thesis (Skripsi) |
|---|---|
| Additional Information: | [No.Panggil: 2210211002] [Pembimbing 1: Feda Anisah Makkiyah] [Pembimbing 2: Adi Sukrisno] [Penguji : Karina] |
| Uncontrolled Keywords: | MCAO, ischemic stroke, brain infarction, TTC, HE staining |
| Subjects: | R Medicine > RD Surgery R Medicine > RZ Other systems of medicine |
| Divisions: | Fakultas Kedokteran > Program Studi Kedokteran (S1) |
| Depositing User: | M. GHERRIANDI RAJA BUANA |
| Date Deposited: | 10 Apr 2026 03:22 |
| Last Modified: | 10 Apr 2026 03:22 |
| URI: | http://repository.upnvj.ac.id/id/eprint/40953 |
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