EFEKTIVITAS PENGGUNAAN OBAT ANTIDIABETES ORAL PADA PASIEN DIABETES MELITUS TIPE 2 DI RUMAH SAKIT ANNISA CIKARANG UTARA

Rifdah Azmi Mardhiyah, . (2025) EFEKTIVITAS PENGGUNAAN OBAT ANTIDIABETES ORAL PADA PASIEN DIABETES MELITUS TIPE 2 DI RUMAH SAKIT ANNISA CIKARANG UTARA. Skripsi thesis, Universitas Pembangunan Nasional Veteran Jakarta.

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Abstract

Objective: The increasing prevalence of type 2 diabetes mellitus (T2DM) poses not only a global challenge but also a significant local health burden, including in West Java Province, particularly in Bekasi City. If poorly managed, this condition can lead to chronic hyperglycemia and long-term organ damage. Therefore, effective pharmacological interventions are required to achieve optimal glycemic control, particularly using oral antidiabetic drugs (OADs). Methods: This study aimed to evaluate the effectiveness of OAD monotherapy, dual therapy, and triple therapy on the reducing of HbA1C levels among T2DM patients at Annisa Hospital, North Cikarang. The study employed an observational design with a cross-sectional approach. A total of 192 samples were selected using purposive sampling. Data were collected from the medical records of T2DM patients receiving OAD therapy during 2022–2024 and analyzed using univariate and bivariate tests (Kruskal–Wallis and post hoc Mann–Whitney tests). Results: Univariate analysis showed the highest distribution in monotherapy (metformin and gliquidone) of 34.37%, dual therapy (metformin + glimepiride) of 56.25%, and triple therapy (metformin + glimepiride + acarbose) of 62.50%. Bivariate analysis demonstrated a significant change in HbA1C levels after OAD administration (p = 0.007). Conclusion: Triple OAD therapy (metformin, glibenclamide, and acarbose) was found to be the most effective regimen in reducing HbA1C levels among T2DM patients at Annisa Hospital, North Cikarang.

Item Type:	Thesis (Skripsi)
Additional Information:	[No.Panggil: 2210211004] [Pembimbing 1: Hany Yusmaini] [Pembimbing 2: Yanti Harjono Hadiwiardjo] [Penguji: Citra Ayu Aprilia]
Uncontrolled Keywords:	Type 2 diabetes mellitus, oral antidiabetic therapy, HbA1C, therapeutic effectiveness
Subjects:	R Medicine > RM Therapeutics. Pharmacology R Medicine > RS Pharmacy and materia medica
Divisions:	Fakultas Kedokteran > Program Studi Kedokteran (S1)
Depositing User:	RIFDAH AZMI MARDHIYAH
Date Deposited:	10 Apr 2026 03:44
Last Modified:	10 Apr 2026 07:46
URI:	http://repository.upnvj.ac.id/id/eprint/40838

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