Grace Jovitha, . (2025) UJI EFEKTIVITAS EKSTRAK BUAH PARIJOTO (Medinilla speciosa Blume) TERHADAP GAMBARAN HISTOPATOLOGI GINJAL MENCIT JANTAN (Mus musculus L) GALUR BALB/C DIET TINGGI LEMAK. Skripsi thesis, Universitas Pembangunan Nasional Veteran Jakarta.
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Abstract
Background: Hyperlipidemia is a major risk factor for chronic kidney disease (CKD), as it can trigger inflammation, oxidative stress, and tissue damage in the kidneys. The use of natural substances such as parijoto fruit extract (Medinilla speciosa Blume), which contains high levels of flavonoids and antioxidants, is considered a potential alternative therapy. This study aimed to determine the effect of parijoto fruit extract on kidney histopathology in BALB/c male mice induced with a high-fat diet. Methods: This was an experimental study using a post-test only control group design. Thirty male BALB/c mice were divided into six groups: K0 (normal control), K- (high-fat diet without treatment), K+ (high-fat diet with simvastatin), and three treatment groups (P1, P2, P3) that received graded doses of parijoto extract. The observed parameters included inflammatory cell infiltration, fatty degeneration, and tubular necrosis. Data were analyzed using Kruskal-Wallis and Mann-Whitney tests. Results: The K- group led most severe kidney tissue damage. Simvastatin (K+) reduced the severity of tissue damage, while the P2 group (moderate dose of parijoto extract) showed the best improvement, with histopathology scores closest to the normal control. In contrast, the P3 group (high dose) exhibited increased tissue damage. Conclusion: Parijoto fruit extract at a moderate dose (P2) was better at achieving simvastatin in improving the kidney histopathology of mice receiving a high-carb diet. High doses are not recommended due to their potential to worsen tissue damage.
| Item Type: | Thesis (Skripsi) |
|---|---|
| Additional Information: | [No. Panggil: 1810211127] [Pembimbing 1: Maria Selvester Thadeus] [Pembimbing 2: Fajriati Zulfa] [Penguji: Nurfitri Bustamam] |
| Uncontrolled Keywords: | Parijoto extract, kidney, hyperlipidemia, histopathology, high-fat diet |
| Subjects: | R Medicine > R Medicine (General) R Medicine > RB Pathology R Medicine > RM Therapeutics. Pharmacology |
| Divisions: | Fakultas Kedokteran > Program Studi Kedokteran (S1) |
| Depositing User: | GRACE JOVITHA |
| Date Deposited: | 19 Aug 2025 01:22 |
| Last Modified: | 19 Aug 2025 01:22 |
| URI: | http://repository.upnvj.ac.id/id/eprint/38371 |
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