Mutiara Nur Azizah, . (2025) EFEK SINERGISME AKTIVITAS ANTIBAKTERI KOMBINASI EKSTRAK ETANOL DAN MINYAK ATSIRI BUAH ANDALIMAN DENGAN AMOKSISILIN DAN TETRASIKLIN TERHADAP Pseudomonas aeruginosa. Skripsi thesis, Universitas Pembangunan Nasional Veteran Jakarta.
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Abstract
Synergism is the result of the interaction of two combinations aimed at overcoming antibiotic resistance. Pseudomonas aeruginosa is a bacterium with a high level of resistance to antibiotics, especially amoxicillin and tetracycline. This study aims to determine the synergistic effect between 70% ethanol extract and essential oil of andaliman fruit with the two antibiotics. The Minimum Inhibitory Concentration (MIC), Minimum Bactericidal Concentration (MBC), and Fractional Inhibitory Concentration Index (FICI) values were tested. The results showed that the MIC and MBC of 70% ethanol extract were 2500 ppm, while the essential oil was 2500 ppm and >2500 ppm, respectively. Amoxicillin showed a MIC of 125 ppm and a MBC of >250 ppm, while the MIC of tetracycline was 62.5 ppm and the MBC was 250 ppm.. The FICI value in the combination of 70% ethanol extract of andaliman fruit with amoxicillin and tetracycline and the combination of essential oil of andaliman fruit with amoxicillin and tetracycline produced a synergistic effect, respectively 0.4479; 0.3957; 0.3645; and 0.2917. Statistical tests showed no significant difference between the combination of 70% ethanol extract with antibiotics and the combination of essential oil with antibiotics (Asymp. Sig 0.704).
| Item Type: | Thesis (Skripsi) |
|---|---|
| Additional Information: | [No.Panggil: 2110212026] [Pembimbing: Eldiza Puji Rahmi} [Penguji 1: Annisa Farida Muti] [Penguji 2: Via Rifkia] |
| Uncontrolled Keywords: | Amoxicillin, Andaliman, P. aeruginosa, Synergism, Tetracycline |
| Subjects: | Q Science > QR Microbiology |
| Divisions: | Fakultas Kedokteran > Program Studi Farmasi (S1) |
| Depositing User: | MUTIARA NUR AZIZAH |
| Date Deposited: | 21 Aug 2025 02:12 |
| Last Modified: | 21 Aug 2025 02:12 |
| URI: | http://repository.upnvj.ac.id/id/eprint/38227 |
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