THE EXPRESSION ANALYSIS OF TGF-Β1. IGF. AND FGF ON SUPERFICIAL AND DEEP OSTEOCHONDRAL DEFECTS OF KNEE JOINT IN SPRAGUE DAWLEY RATS (PRELIMINARY STUDY)

Basuki Supartono, - (2017) THE EXPRESSION ANALYSIS OF TGF-Β1. IGF. AND FGF ON SUPERFICIAL AND DEEP OSTEOCHONDRAL DEFECTS OF KNEE JOINT IN SPRAGUE DAWLEY RATS (PRELIMINARY STUDY). The 6th Indonesian Biotechnology Conference Enhancing Industrial Competitiveness Through Biotechnology Inovation . Universitas Sebelas Maret, Surakarta. ISBN 978-602-14235-6-1

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Abstract

The growth factor is one of the elements that contribute to healing and regeneration of osteochondral defects in knee joint. Stem cell work together with growth factors to produce tissue regeneration. The timing of growth factor expression is very important to determine the timing of observation, during stem cell intervention in osteochondral defect. Here, we showed that TGF-β1, IGF and FGF expressed on chondrocyte cells in osteochondral defect of Sprague Dawley rats temporally. Early expression was observed after 7 days post defect, and disappeared on day 28th . Macroscopic examination exhibit improvement on day 7. The morphogical improvement stayed until day 28th post defect. Taken together, the osteochondral defect induced the expression of TGF-β1, IGF, and FGF temporarily.

Item Type: Book
Subjects: R Medicine > RZ Other systems of medicine
Divisions: Fakultas Kedokteran > Program Studi Kedokteran (S1)
Depositing User: Saidun Sinaga
Date Deposited: 11 Jun 2019 05:41
Last Modified: 14 Jun 2019 08:17
URI: http://repository.upnvj.ac.id/id/eprint/377

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