PENGARUH PEMBERIAN LARUTAN GULA AREN (Arenga pinnata) TERHADAP MORFOLOGI SPERMATOZOA TIKUS PUTIH (Rattus Norvegicus L.) GALUR WISTAR MODEL DIABETES MELITUS

Rahmi Aulia Lesmana, . (2025) PENGARUH PEMBERIAN LARUTAN GULA AREN (Arenga pinnata) TERHADAP MORFOLOGI SPERMATOZOA TIKUS PUTIH (Rattus Norvegicus L.) GALUR WISTAR MODEL DIABETES MELITUS. Skripsi thesis, Universitas Pembangunan Nasional Veteran Jakarta.

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Abstract

Objective Hyperglicemia in diabetic patients can increase ROS production, which causes oxidative stress and damage cells in the body, including causing negative impacts on male reproductive function. One of the herbal plants, namely palm sugar (Arenga pinnata), is known to have antioxidant activity. The aim of this study is to determine the effect of palm sugar solution on the morphology of spermatozoa in diabetic rats, to compare the morphological characteristics of spermatozoa in treated rats with those in the control group, and to identify the optimal dose of palm sugar solution for improving spermatozoa morphology in diabetic rats. Method This study used a true experiment method with a post-test-only control group design. The research sample was 30 Wistar male white rats, weighing 175-350 grams, aged 2-3 months, selected through simple random sampling and then divided into five groups: the negative control group, which received standard feed; the positive control group, which was induced by alloxan; and treatment groups 1, 2, 3 induced by alloxan then given palm sugar solution at doses of 90, 180 and 360 (mg/kgBB/day) for 28 days. Rats were anaesthetized with Ketamine Xylazine and then dissected. The epididymis organs were taken and chopped, then homogenized with NaCl physiological fluid. Preparation was done using Giemsa staining, and then the morphology of spermatozoa was observed with a microscope. Result The One Way Anova test showed that there is an effect of palm sugar solution on the morphology of spermatozoa in diabetic Wistar rats (p=0.001). Based on the Bonferroni Post-Hoc test results, the administration of palm sugar solution at a dose of 90 mg/kgBW/day was significant compared to the positive control group (p=0.007), making it the most effective dose in improving the morphological quality of spermatozoa in diabetic rats. Conclusion The research findings indicate that palm sugar solution (Arenga pinnata) can affect the morphology of spermatozoa in Wistar strain white rats (Rattus norvegicus) in a diabetes mellitus model.

Item Type: Thesis (Skripsi)
Additional Information: [No. Panggil: 2110211077] [Pembimbing 1: Boenga NurCita] [Pembimbing 2: Maulidya Ayudika Dandanah] [Penguji 1: Nasihin Saud Irsyad]
Uncontrolled Keywords: Diabetes Mellitus, Extract of Arenga pinnata, Rattus norvegicus, ROS, Sperm Morphology.
Subjects: Q Science > Q Science (General)
R Medicine > R Medicine (General)
Divisions: Fakultas Kedokteran > Program Studi Kedokteran (S1)
Depositing User: RAHMI AULIA LESMANA
Date Deposited: 06 Feb 2025 13:28
Last Modified: 10 Mar 2025 04:35
URI: http://repository.upnvj.ac.id/id/eprint/34872

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