Yasmin Khaila Marshanda, . (2025) PENGARUH EKSTRAK DAUN UBI JALAR UNGU (IPOMOEA BATATAS L) TERHADAP PERBAIKAN HISTOPATOLOGI GINJAL TIKUS WISTAR MODEL DIABETIK. Skripsi thesis, Universitas Pembangunan Nasional Veteran Jakarta.
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Abstract
ABSTRACT Objective Hyperglycemia in diabetes mellitus can cause end-stage renal disease with high mortality and morbidity rates. Alternative therapy using purple sweet potato leaf extract (Ipomoea batatas L) contains antioxidants flavonoids, tannins, saponins and polyphenols able to reduce kidney damage due to diabetes mellitus by reducing buildup free radicals The aim of this research is to determine the effect of purple sweet potato leaf extract (PSPLE) on improving kidney histopathology in white rat (Rattus norvegicus) diabetic model Wistar strain. Method The research design is pure experimental use posttest only control group design. Samples of 30 Wistar rats, weighing 200-300 grams, and aged 2-3 months were taken randomly. simple random sampling. The rats were divided into the following groups: K1 (standard feed and distilled water), K2 (alloxan), K3 (alloxan and simvastatin), and P1, P2, P3 {alloxan and EDUJU at doses of 150, 300, and 600 mg/kgBW}, with all groups except K1 receiving a high-fat diet. The treatments were administered over a period of 18 days. The rats were anesthetized using Ketamine-Xylazine, dissected to extract the kidneys, and kidney preparations were made using Hematoxylin-Eosin (HE) staining. Result The results of the Kruskal Wallis test showed an effect of EDUJU on improving the kidney histopathology of diabetic Wistar rats (p=0.038). Post-Hoc Mann Whitney test giving PSPLE at a dose of 600 mg/kgBW was almost the same as simvastatin (p=0.475). Conclusion Based on the result purple sweet potato leaf extract can improve kidney histopathological damage due to diabetes mellitus. Keywords : Antioxidant, Diabetes Mellitus, Free Radicals, Kidney Histopathology Purple Sweet Potato Leaf Extract
| Item Type: | Thesis (Skripsi) |
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| Additional Information: | No Panggil: 2110211015 Pembimbing 1: Kristina Simanjuntak Pembimbing 2: Mila Citrawati Penguji: Citra Ayu Aprilia |
| Uncontrolled Keywords: | Keywords: Antioxidant, Diabetes Mellitus, Free Radicals, Kidney Histopathology Purple Sweet Potato Leaf Extract |
| Subjects: | R Medicine > R Medicine (General) R Medicine > RM Therapeutics. Pharmacology |
| Divisions: | Fakultas Kedokteran > Program Studi Kedokteran (S1) |
| Depositing User: | YASMIN KHAILA MARSHANDA |
| Date Deposited: | 27 Feb 2025 01:32 |
| Last Modified: | 27 Feb 2025 01:32 |
| URI: | http://repository.upnvj.ac.id/id/eprint/34869 |
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