Rifdah Sasikirana, . (2025) UJI EFEKTIVITAS EKSTRAK ETANOL DAUN SIRIH HIJAU (Piper betle LINN.) DENGAN METODE UAE SEBAGAI ANTIFUNGI TERHADAP PERTUMBUHAN JAMUR Trichophyton rubrum SECARA IN VITRO. Skripsi thesis, Universitas Pembangunan Nasional Veteran Jakarta.
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Abstract
Cases of dermatophytosis in Indonesia are currently quite high, reaching 52%, which is mostly caused by the fungus Trichophyton rubrum. Distribution of antifungal drugs in the community can cause side effects and resistance, so alternative treatments such as green betel leaf extract are needed. This study aims to determine the effectiveness of green betel leaf ethanol extract as an anti-fungal against Trichophyton rubrum. This study was conducted experimentally with a post-test-only control group design using concentrations of 10%, 20%, 30%, and 40% derived from green betel leaf extract, DMSO as negative control and 2% ketoconazole as positive control. The data of this study was taken by measuring the inhibition zones carried out at 24-hour and 48-hour incubation using the disc method. The results of the inhibition zone obtained are different because they are influenced by the concentration of the extract and the incubation time. The active compounds contained in green betel leaf ethanol extract such as alkaloids, flavonoids, tannins, triterpenoids, and polyphenols make this extract can inhibit the growth of Trichophyton rubrum. Based on Davis and Stout (1971), the results of the study on 24-hour and 48-hour incubation showed that all concentrations had weak strength as antifungics. The most effective concentration is 30% at 24-hour incubation with an inhibition zone diameter of 3.97 mm.
| Item Type: | Thesis (Skripsi) |
|---|---|
| Additional Information: | [No. Panggil: 2110211018} [Pembimbing 1: Yuni Setyaningsih] [Pembimbing 2: Retno Yulianti] [Penguji]: Fajriati Zulfa |
| Uncontrolled Keywords: | Disc method; Green betel leaf extract; Inhibition Zone; Tricophyton rubrum |
| Subjects: | R Medicine > R Medicine (General) |
| Divisions: | Fakultas Kedokteran > Program Studi Kedokteran (S1) |
| Depositing User: | RIFDAH SASIKIRANA |
| Date Deposited: | 19 Mar 2025 03:06 |
| Last Modified: | 19 Mar 2025 03:06 |
| URI: | http://repository.upnvj.ac.id/id/eprint/34748 |
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