Ringgo Bharata, . (2024) PENGARUH EKSTRAK DAUN ASAM JAWA (TAMARINDUS INDICA L.) TERHADAP MOTILITAS SPERMA TIKUS PUTIH (RATTUS NORVEGICUS) JANTAN DIABETIK YANG DIINDUKSI ALOKSAN. Skripsi thesis, Universitas Pembangunan Nasional Veteran Jakarta.
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Abstract
Diabetes mellitus (DM) can lead to complications, one of which is male reproductive system disorders. DM induces an increase in Reactive Oxygen Species (ROS) which can interfere with the sperm maturation process and reduce the percentage of spermatozoa motility. Tamarind leaves are known to have antioxidant substances that can break down and counteract free radicals. The aims of the research is to determine the effect of administering tamarind leaf extract on the sperm motility of diabetic rats. The research method is true experimental with post-test only control group design. Subjects were 30 male Wistar strain rats aged 12 weeks with a body weight of 200-210 grams. Subjects were randomly selected and divided into 5 groups: K- (standard food and drink), K+ (alloxan dose 150mg/kg bw), P1 (alloxan and extract dose 75mg/kg bw), P2 (alloxan and extract dose 150mg/kg bw), and P3 (alloxan and extract dose 300mg/kg bw). The study was conducted for 38 days and then the rats were terminated and dissected. The results of the calculation of sperm motility were analyzed with the Kruskal-Wallis non-parametric statistical test and obtained a p value of 0.032 (p <0.05) which indicates that there is an effect of tamarind leaf extract on the sperm motility of diabetic male rats. The conclusion of this study is that the administration of tamarind leaf extract at a dose of 75mg/kg bw and 150mg/kg bw shows a better percentage of rat sperm motility and is significantly different from alloxan-induced diabetic male rats while the administration of a dose of 300mg/kg bw shows a better percentage of rat sperm motility but is not significantly different. This shows that the administration of tamarind leaf extract can prevent the decrease in sperm motility of rats due to DM with an effective dose of 75mg/kg bw.
| Item Type: | Thesis (Skripsi) |
|---|---|
| Additional Information: | [No. Panggil; 2110211008] [Pembimbing: Cut Fauziah] [Penguji 1: Abdul Kolib] [Penguji 2: Boenga NurCita] |
| Uncontrolled Keywords: | Diabetes Mellitus, ROS, Sperm Motility, Tamarind Leaf Extract, Wistar Rats. |
| Subjects: | R Medicine > R Medicine (General) R Medicine > RM Therapeutics. Pharmacology R Medicine > RS Pharmacy and materia medica |
| Divisions: | Fakultas Kedokteran > Program Studi Kedokteran (S1) |
| Depositing User: | RINGGO BHARATA |
| Date Deposited: | 14 Mar 2025 03:31 |
| Last Modified: | 14 Mar 2025 03:31 |
| URI: | http://repository.upnvj.ac.id/id/eprint/34725 |
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