OPTIMASI EKSTRAK BUAH ANDALIMAN (ZANTHOXYLUM ACANTHOPODIUM DC) DENGAN RESPONSE SURFACE METHODOLOGY TERHADAP KADAR FLAVONOID TOTAL DAN AKTIVITAS INHIBISI ENZIM ASETILKOLINESTERASE

Annisa Hana Mufidah, . (2024) OPTIMASI EKSTRAK BUAH ANDALIMAN (ZANTHOXYLUM ACANTHOPODIUM DC) DENGAN RESPONSE SURFACE METHODOLOGY TERHADAP KADAR FLAVONOID TOTAL DAN AKTIVITAS INHIBISI ENZIM ASETILKOLINESTERASE. Skripsi thesis, Universitas Pembangunan Nasional Veteran Jakarta.

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Abstract

Alzheimer's is a neurodegenerative disease with decreased cognitive and non-cognitive functions in patients. The pathogenesis of Alzheimer's disease is thought to be due to a decrease in acetylcholine levels in the brain, so one therapeutic approach to slowing its progress is through the inhibition of acetylcholinesterase (AChE). Andaliman (Z. acanthopodium) has the potential to exhibit AChE inhibitory activity due to the flavonoid content in the fruit. This paper studied the optimization of andaliman fruit extraction with the influence factor of microwave power (270–630 W) and extraction time duration (10–30 s) using a Central Composite Design through the Design Expert 13.0 program. From the optimized extract, the total flavonoid content (TFC) was studied using the colorimetric method (AlCl3) and the acetylcholinesterase inhibitory activity using the Ellman method. Microwave power results in a p-value <0.05, while extraction time results in a p-value>0.05. Optimum conditions were obtained with a desirability value of 0.987 for extracting andaliman fruit using 70% ethanol solvent, determined at 450 W microwave power and 10 s extraction time which resulted a TFC of 70,5923 mg QE/g extract and an inhibitory activity of 35,098% at a concentration of 2 mg/ml extract. The method was verified and analyzed based on residual standard error which resulted in a value <5%. These results indicate that the central composite design can optimize flavonoid compounds with AChE inhibitory activity from Z. acanthopodium fruit.

Item Type: Thesis (Skripsi)
Additional Information: [No.Panggil: 2010212024] [Pembimbing 1: Eldiza Puji Rahmi] [Pembimbing 2: Dhigna Luthfiyani Citra Pradana] [Penguji: Via Rifkia]
Uncontrolled Keywords: Acetylcholinesterase Inhibitor, Response Surface Methodology, Total Flavonoid Content, Zanthoxylum acanthopodium
Subjects: R Medicine > RS Pharmacy and materia medica
Divisions: Fakultas Kedokteran > Program Studi Farmasi (S1)
Depositing User: ANNISA HANA MUFIDAH
Date Deposited: 30 Aug 2024 07:59
Last Modified: 30 Aug 2024 07:59
URI: http://repository.upnvj.ac.id/id/eprint/32528

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