KANDUNGAN FENOLIK TOTAL DAN FLAVONOID TOTAL SERTA AKTIVITAS INHIBISI ENZIM TIROSINASE PADA EKSTRAK DAUN KELOR DENGAN ULTRASONIK SECARA IN VITRO

Nafilah Syffa, . (2024) KANDUNGAN FENOLIK TOTAL DAN FLAVONOID TOTAL SERTA AKTIVITAS INHIBISI ENZIM TIROSINASE PADA EKSTRAK DAUN KELOR DENGAN ULTRASONIK SECARA IN VITRO. Skripsi thesis, Universitas Pembangunan Nasional Veteran Jakarta.

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Abstract

Ultraviolet (UV) radiation results in excess melanin synthesis in the body, causing various skin problems. The tyrosinase enzyme plays an important role in the melanin synthesis process. Moringa leaves (Moringa oleifera L) contain many flavonoids and phenolic compounds that act as tyrosinase enzyme inhibitors. This study aims to analyze the total henolic content and total flavonoids as well as tyrosinase enzyme inhibitory activity in vitro in ethanol extract of Moringa leaves with Ultrasound Assisted Extraction (UAE) frequency variations of 30 kHz, 40 kHz, and 50 kHz based on true experimental with post-test only with control group design. The test results of total phenolic content and total flavonoid content had the highest value at a frequency of 40 kHz at 383.90 mgGAE/g and 53 mgQE/g. Tyrosinase enzyme inhibition test conducted with enzymatic microplate reader, obtained the highest tyrosinase enzyme inhibition value at a frequency of 50 kHz with a value of 15,550.79 ppm. The results of enzyme inhibition were then analyzed by Kruskal-Wallis test and Mann-Whitney test, based on the test results there were differences between frequency variations on IC50 values but not significant (p>0.05) and Pearson correlation between frequency variations and IC50 values was negative and very strong.

Item Type: Thesis (Skripsi)
Additional Information: [No.Panggil: 2010212012] [Pembimbing 1: Annisa Farida Muti] [Pembimbing 2: Rika Revina] [Penguji Utama: Via Rifkia]
Uncontrolled Keywords: Moringa leaf Tyrosinase enzyme IC50 Total phenolic and flavonoid content Ultrasound assisted extraction
Subjects: Q Science > Q Science (General)
Divisions: Fakultas Kedokteran > Program Studi Farmasi (S1)
Depositing User: NAFILAH SYFFA
Date Deposited: 09 Sep 2024 03:11
Last Modified: 09 Sep 2024 03:11
URI: http://repository.upnvj.ac.id/id/eprint/32042

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