Bintang Yudha Wibowo, . (2024) PENGARUH PEMBERIAN EKSTRAK DAUN SUKUN (ARTOCARPUS ALTILIS) TERHADAP VIABILITAS SPERMATOZOA TIKUS JANTAN DIABETIK YANG DIINDUKSI STREPTOZOTOSIN. Skripsi thesis, Universitas Pembangunan Nasional Veteran Jakarta.
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Abstract
Infertility is a common complication in men with diabetes mellitus caused by oxidative stress and peroxidative damage. Among many natural products as an alternative herbal therapy for infertility, flavonoids have been extensively researched for the treatment of male reproductive system dysfunction. The study aims to determine the effect of the administration of leaf extract on the viability of spermatozoa in diabetic male rats induced by streptozotosin. In this study, thirty males were grouped into five groups. The negative control group did not receive treatment, the positive control group received a peritoneal injection of streptozotosin 40 mg/kgBB, the P1-P3 treatment group was given a peritoineal streptocotosin injetion of 40mg/kgBT and successively given leaf extract of 200, 400, 800 mg/ kgBB. The mice were then terminated after 31 days and the viability of sperm was tested. The data was analyzed using descriptive and analytical methods using the One Way ANOVA test and the Games-Howell post-hoc test. The results of this study showed a decrease in viability between negative and positive controls, as well as an increase between the positive control group and the treatment group given leaf extract. The group that received 400 mg/kg of leaf extract showed the highest improvement. The leaf extract has strong anti-hydroxyl radicals and DPPH activity which can significantly improve the viability of Wistar mice's sperm with diabetes mellitus. Cucumber leaves contain antioxidant compounds that have been shown to help in healing oxidative stress.
| Item Type: | Thesis (Skripsi) |
|---|---|
| Additional Information: | No.Panggil: 2010211110 Pembimbing 1: Cut Fauziah Pembimbing 2: Hany Yusmaini Penguji: Citra Ayu Aprilia |
| Uncontrolled Keywords: | Breadfruit Leaves, Diabetes Mellitus, Infertility, Sperm Viability |
| Subjects: | Q Science > QH Natural history > QH301 Biology R Medicine > RM Therapeutics. Pharmacology |
| Divisions: | Fakultas Kedokteran > Program Studi Kedokteran (S1) |
| Depositing User: | BINTANG YUDHA WIBOWO |
| Date Deposited: | 02 Oct 2024 01:30 |
| Last Modified: | 02 Oct 2024 01:30 |
| URI: | http://repository.upnvj.ac.id/id/eprint/30939 |
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