Annisa Waliyyam Mursyida, . (2024) UJI AKTIVITAS ANTIBAKTERI EKSTRAK DAUN KEMBANG SEPATU (Hibiscus rosa sinensis Linn.) TERHADAP PERTUMBUHAN BAKTERI PENYEBAB ENDOKARDITIS INFEKTIF: Studi In Vitro. Skripsi thesis, Universitas Pembangunan Nasional Veteran Jakarta.
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Abstract
Infective endocarditis is an infectious disease of microorganisms in the endocardium of the heart valves (native or prosthetic), septum, or heart murals. The disease is commonly caused by gram�positive bacteria, such as Staphylococcus aureus (44%) and Streptococcus viridans (20 25%). Hibiscus rosa sinensis L. leaves are known to have antibacterial potential. This study aims to test the activity of hibiscus leaf extract with 70% ethanol maceration and antibacterial test using disc diffusion method (Kirby-Bauer) with Mueller Hinton Agar (MHA) universal media to see the inhibition zone formed around the disc. The number of replicates of each treatment group was 4 times which was calculated by the Federer formula. The results of this study indicate that hibiscus leaf extract is able to inhibit the growth of S. aureus at concentrations of 25%, 50%, 75%, and 100% with the average diameter of the inhibition zone formed of 2,04±0,309 mm, 2,90±0,615 mm, 4,09±0,576 mm, 4,83±0,548 mm and can inhibit the growth of S. viridans at the same concentration with the inhibition zone formed of 1,17±0,396 mm, 3,43±0,663 mm, 4,69±0,266 mm, dan 7,70±1,025 mm. The Mann-Whitney test results showed that there were significant differences in each test group of S. aureus (p<0.05) and S. viridans (p<0.05), except for the 75% concentration against 100% in S. aureus (p>0.05). The most effective concentration of hibiscus leaf extract in inhibiting the growth of S. aureus and S. viridans is 100% concentration but not as effective as the positive control ceftriaxone.
| Item Type: | Thesis (Skripsi) |
|---|---|
| Additional Information: | [No. Panggil: 1810211089] [Penguji: Maria Selvester Thadeus] [Pembimbing 1: Imam Prabowo] [Pembimbing 2: Annisa Farida Muti] |
| Uncontrolled Keywords: | 70% ethanol extract, Hibiscus rosa-sinensis Linn., Staphylococcus aureus, Streptococcus viridans, antibacterial |
| Subjects: | Q Science > QR Microbiology R Medicine > R Medicine (General) R Medicine > RS Pharmacy and materia medica |
| Divisions: | Fakultas Kedokteran > Program Studi Kedokteran (S1) |
| Depositing User: | Annisa Waliyyam Mursyida |
| Date Deposited: | 04 Apr 2024 05:47 |
| Last Modified: | 04 Apr 2024 05:47 |
| URI: | http://repository.upnvj.ac.id/id/eprint/28689 |
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