PERBANDINGAN EFEKTIVITAS ANTIBAKTERI EKSTRAK DAUN UNGU (Graptophyllum Pictum (L.) Griff) MENGGUNAKAN METODE ULTRASONIK DAN MASERASI TERHADAP PERTUMBUHAN SHIGELLA DYSENTERIAE

MOHAMMAD IKHLAS YANUAR, . (2023) PERBANDINGAN EFEKTIVITAS ANTIBAKTERI EKSTRAK DAUN UNGU (Graptophyllum Pictum (L.) Griff) MENGGUNAKAN METODE ULTRASONIK DAN MASERASI TERHADAP PERTUMBUHAN SHIGELLA DYSENTERIAE. Skripsi thesis, Universitas Pembangunan Nasional Veteran Jakarta.

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Abstract

Shigellosis is a diarrheal disease caused by Shigella dysenteriae bacteria. Purple leaf (Graptophyllum pictum (L.) Griff) which are used as herbal plants contain secondary metabolic compounds, such as flavonoids, tannins, and alkaloids which function to inhibit the growth of S. dysenteriae bacteria. The content of these secondary metabolic compounds can be obtained using ultrasonic extraction and maceration methods. This study aims to determine the comparison of the antibacterial effectiveness of purple leaf extract using ultrasonic and maceration methods on the growth of S. dysenteriae. The research design was truly experimental and carried out in vitro. The research samples were divided into 2 methods, namely maceration and ultrasonic, each of which was divided into 5 treatment groups. This group consisted of treatment with dilution concentrations of 60% (K1), 70% (K2), 80% (K3), positive control using chloramphenicol (K4), and negative control (K5). Each treatment used the well diffusion method to test antibacterial activity and the inhibition zone formed after 1 day was measured. The results of the One-Way ANOVA test showed a significant difference (p= 0.000) and in the Post-Hoc Bonferroni test, both methods at all dilution concentrations were close to the negative control (p= 0.000). The results of the Independent Sample T-test of ultrasonic and maceration groups in dilution concentrations of 60%, 70%, and 80% generate p-value of 0.002; 0.004; 0,004 respectively. There is a significant difference between purple leaf extract using the ultrasonic method and maceration because the ultrasonic method can produce pure extracts and higher yields

Item Type: Thesis (Skripsi)
Additional Information: [No.Panggil: 2010211098] [Pembimbing 1: Meiskha Bahar] [Pembimbing 2: Aulia Chairani] [Penguji: Fajriati Zulfa]
Uncontrolled Keywords: Antibacterial, purple leaves, maceration, Shigella dysenteriae, ultrasonic
Subjects: Q Science > QR Microbiology
Divisions: Fakultas Kedokteran > Program Studi Kedokteran (S1)
Depositing User: Mohammad Ikhlas Yanuar
Date Deposited: 21 Mar 2024 01:25
Last Modified: 21 Mar 2024 01:25
URI: http://repository.upnvj.ac.id/id/eprint/28170

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