Nur' Alisa, . (2023) UJI TOKSITAS INFUSA TUMBUHAN SURUHAN (PEPEROMIA PELLUCIDA L. KUNTH) SECARA INVITRO DENGAN METODE BRINE SHRIMP LETHALITY TEST (BSLT). Skripsi thesis, Universitas Pembangunan Nasional Veteran Jakarta.
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Abstract
Suruhan (Peperomia pellucida L. Kunth) is one of the plants from the Piperaceae family that has long been traditionally used to reduce blood uric acid levels, cholesterol, blood pressure, and to treat various diseases such as boils, acne, abscesses, and stomachaches because its known contain of various bioactive compounds that have therapeutic effects, including flavonoids, tanins, saponins, triterpenoids, steroids, and alkaloids. This study aims to determine the lethal concentration (LC50) value of suruhan leaf infusion using in vitro method the Brine Shrimp Lethality Test (BSLT). Toxicity testing used four concentration treatments namely 10 ppm, 100 ppm, 500 ppm, and 1000 ppm, along with a negatif control, and conducted as many as three repetitions for each treatment. Ten larvae of Artemia salina Leach were used for each concentration, and the number of larvae that died was counted after 24 hours of treatment. Based on phytochemical screening test, suruhan leaves infusion contains flavonoids, alkaloids, saponins and tanins. The BSLT test revealed that the LC50 value of suruhan leaf infusion is 304.92 ppm and belongs to the moderate toxicity category. The difference in LC50 value with previous studies can be caused by differences of extraction methods and solvents used, as well as differences in location of the sample which is suruhan plant obtained.
| Item Type: | Thesis (Skripsi) |
|---|---|
| Additional Information: | [No.Panggil : 1810211030] [Pembimbing 1 : Citra Ayu Aprilia] [Pembimbing 2 : Dhigna Luthfiyani Citra Pradana] [Penguji : Erna Harfiani] |
| Uncontrolled Keywords: | Suruhan Leaf Infusion, BSLT, Artemia salina Leach, Acute toxicity, LC50 |
| Subjects: | R Medicine > R Medicine (General) R Medicine > RM Therapeutics. Pharmacology R Medicine > RS Pharmacy and materia medica |
| Divisions: | Fakultas Kedokteran > Program Studi Kedokteran (S1) |
| Depositing User: | Nur' Alisa |
| Date Deposited: | 05 Mar 2024 07:14 |
| Last Modified: | 05 Mar 2024 07:14 |
| URI: | http://repository.upnvj.ac.id/id/eprint/27992 |
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