EFEKTIVITAS PEMBERIAN EKSTRAK KULIT TERUNG UNGU (Solanum melongena L.) TERHADAP KADAR HDL PADA TIKUS GALUR WISTAR DIABETIK

Risda Kaemia, . (2024) EFEKTIVITAS PEMBERIAN EKSTRAK KULIT TERUNG UNGU (Solanum melongena L.) TERHADAP KADAR HDL PADA TIKUS GALUR WISTAR DIABETIK. Skripsi thesis, Universitas Pembangunan Nasional Veteran Jakarta.

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Abstract

Diabetes mellitus can cause macrovascular complications such as dyslipidemia, atherosclerosis, and coronary heart disease, which cause the highest mortality rate in the world, so supportive therapy is needed to improve lipid profiles. The purpose of the study was to determine the effectiveness of purple eggplant skin extract on HDL cholesterol. The research design was post-test only control group design, with a sample of 30 male Wistar rats weighing 150-200 grams aged 2-3 months by simple random sampling. Rats were divided into groups of standard feed and distilled water (K1), alloxan (K2) simvastatin (K3), and purple eggplant skin extract doses {75;150;300 (mg/dl)} (K4 K5;K6) with 14 days treatment. Mice were anaesthetised with ketamine xylazie blood was collected and centrifuged in EDTA tubes, and HDL levels were checked. The results of the One-Way ANOVA test obtained p=0,004 and the results of the Bonferroni Post-Hoc test there are significant differences between purple eggplant peel extract (75;150;300)mg kgBB with negative control, but not with positive control (p=1,000). The administration of purple eggplant skin extract 75 mg/KgBB can increase the HDL level of diabetic Wistar rats almost the same as simvastatin. Purple eggplant skin extract has anthocyanin content that can increase HDL levels.

Item Type: Thesis (Skripsi)
Additional Information: [No.Panggil: 2010211021] [Pembimbing: Kristina Simanjuntak] [Pembimbimbing 2: Nugrahayu Widyawardani] [Penguji 1: Citra Ayu Aprilia]
Uncontrolled Keywords: Purple eggplant peel, Diabetic Mellitus, HDL Cholestrol
Subjects: R Medicine > RS Pharmacy and materia medica
Divisions: Fakultas Kedokteran > Program Studi Kedokteran (S1)
Depositing User: Risda Kaemia
Date Deposited: 14 Mar 2024 04:15
Last Modified: 14 Mar 2024 04:15
URI: http://repository.upnvj.ac.id/id/eprint/27921

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