Kharisma Ikhwani, . (2023) POTENSI EKSTRAK DAUN BIDARA (ZIZIPHUS MAURTIANA LAM.) TERHADAP GAMBARAN HISTOPATOLOGI GINJAL TIKUS PUTIH GALUR WISTAR MODEL HIPERLIPIDEMIA. Skripsi thesis, Universitas Pembangunan Nasional Veteran Jakarta.
![[img]](http://repository.upnvj.ac.id/style/images/fileicons/text.png) |
Text
ABSTRAK.pdf Download (210kB) |
|
Text
AWAL.pdf Download (934kB) |
|
Text
BAB 1.pdf Restricted to Repository UPNVJ Only Download (323kB) |
|
Text
BAB 2.pdf Restricted to Repository UPNVJ Only Download (1MB) |
|
Text
BAB 3.pdf Restricted to Repository UPNVJ Only Download (828kB) |
|
Text
BAB 4.pdf Restricted to Repository UPNVJ Only Download (1MB) |
|
Text
BAB 5.pdf Download (306kB) |
|
Text
DAFTAR PUSTAKA.pdf Download (442kB) |
|
Text
RIWAYAT HIDUP.pdf Restricted to Repository UPNVJ Only Download (314kB) |
|
Text
LAMPIRAN.pdf Restricted to Repository UPNVJ Only Download (1MB) |
|
Text
HASIL PLAGIARISME.pdf Restricted to Repository staff only Download (42kB) |
|
Text
ARTIKEL KI.pdf Restricted to Repository staff only Download (534kB) |
Abstract
Abstract: Introduction: Chronic Kidney Disease (CKD) refers to the irreversible decline in kidney function that develops gradually over time. Hyperlipidemia can influence the progression of CKD as it is one of the predisposing factors for diabetic nephropathy with histopathological features such as Interstitial Inflammation and Interstitial Fibrosis and Tubular Atrophy (IFTA). Flavonoids and alkaloids are secondary metabolites found in the leaves of Bidara (Ziziphus mauritiana Lam.) that have therapeutic effects in reducing serum creatinine levels and inhibiting the progression of IFTA and Interstitial Inflammation. Objective: This study aims to determine the potential of Bidara leaf extract (Ziziphus mauritiana Lam.) on the histopathological appearance of the kidneys in high-lipid diet-induced Wistar rats. Method: A true experimental research method with a randomized post-test only control group design was employed, using 30 Wistar rats induced with a high-fat diet, then divided into 5 groups consisting of 2 control groups and 3 treatment groups with Bidara Leaf Extract at doses of 0.2 gr/kgBW, 0.4 gr/kgBW, 0.8 gr/kgBW. The Kruskal-Wallis Analysis and Post-Hoc Mann Whitney Test were used for analysis. Results: Bivariate analysis results obtained showed significance (P-value < 0.05). Conclusion: It can be concluded that Bidara Leaf Extract (Ziziphus mauritiana Lam.) inhibits the progression of IFTA and Interstitial Inflammation lesions and has therapeutic effects comparable to orlistat if the given dose is adequate. Keywords: Bidara Leaf, Orlistat, Histopathology, IFTA, Interstitial Inflammation.
| Item Type: | Thesis (Skripsi) |
|---|---|
| Additional Information: | [No. Panggil : 2010211001] [Pembimbing 1 : Maria Selvester Thadeus] [Pembimbing 2 : Hikmah Muktamiroh] [Penguji : Kristina Simanjuntak] |
| Uncontrolled Keywords: | Bidara Leaf, Orlistat, Histopathology, IFTA, Interstitial Inflammation. |
| Subjects: | R Medicine > R Medicine (General) R Medicine > RB Pathology R Medicine > RS Pharmacy and materia medica |
| Divisions: | Fakultas Kedokteran > Program Studi Kedokteran (S1) |
| Depositing User: | Kharisma Ikhwani |
| Date Deposited: | 13 Mar 2024 01:24 |
| Last Modified: | 13 Mar 2024 01:24 |
| URI: | http://repository.upnvj.ac.id/id/eprint/27758 |
Actions (login required)
 |
View Item |