EVALUASI KEJADIAN EFEK SAMPING OBAT ANTI TUBERKULOSIS KOMBINASI DOSIS TETAP DAN KOMBIPAK PADA PASIEN TUBERKULOSIS PARU DI RSUD SUMEDANG TAHUN 2022

Menik Wijayanti Maharani, . (2023) EVALUASI KEJADIAN EFEK SAMPING OBAT ANTI TUBERKULOSIS KOMBINASI DOSIS TETAP DAN KOMBIPAK PADA PASIEN TUBERKULOSIS PARU DI RSUD SUMEDANG TAHUN 2022. Tugas Akhir thesis, Universitas Pembangunan Nasional Veteran Jakarta.

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Abstract

Indonesia is ranked second in the number of tuberculosis cases in the world, especially in West Java province. Tuberculosis (TB) is an infectious disease caused by the bacterium Mycobacterium tuberculosis. The anti-tuberculosis drug guide contains four types of drugs (Isoniasid, Rifampicin, Pyrazinamid, and Ethambutol). Guidelines for tuberculosis treatment in Indonesia include two types of fixed-dose combination anti-tuberculosis drug packages (FDC) and separated formulation with different dosage forms. This affects the occurrence of side effects. This study aims to evaluate the side effects of FDC and separated formulation in pulmonary tuberculosis patients at Sumedang Regional Hospital in 2022. This study was a cross-sectional observational study with 60 samples selected by consecutive sampling. Data were collected from patients' medical records and analyzed using univariate and bivariate Chi-square tests. The results of univariate analysis found that the characteristics of most research subjects were over 60 years old and male. The most use of anti-tuberculosis drugs is FDC which is 65% with the most side effects are mild side effects which are 66.7%. The results of bivariate analysis found that there was a relationship between dosage forms and side effects with a value of p = 0.022. The use of FDC tends to increase the incidence of side effects compared to separated formulation.

Item Type: Thesis (Tugas Akhir)
Additional Information: [No.Panggil: 2010211007] [Pembimbing 1: Hany Yusmaini] [Pembimbing 2: Karina] [Penguji: Erna Harfiani]
Uncontrolled Keywords: tuberculosis, fixed dose combination, separated drugs, side effect
Subjects: R Medicine > R Medicine (General)
R Medicine > RM Therapeutics. Pharmacology
Divisions: Fakultas Kedokteran > Program Studi Kedokteran (S1)
Depositing User: Menik Wijayanti Maharani
Date Deposited: 07 Mar 2024 07:27
Last Modified: 07 Mar 2024 07:27
URI: http://repository.upnvj.ac.id/id/eprint/27648

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