Nuhaa Zuhdiyyah, . (2023) AKTIVITAS INHIBISI ENZIM ALFA-GLUKOSIDASE EKSTRAK DAUN JOMBANG (TARAXACUM OFFICINALE) SECARA IN VITRO. Skripsi thesis, Universitas Pembangunan Nasional Veteran Jakarta.
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Abstract
Type 2 diabetes mellitus (DM) is a metabolic disorder characterized by hyperglycemia due to insulin resistance. One of the therapies for lowering blood sugar levels is using drugs that inhibit the alpha-glucosidase enzyme. The alpha-glucosidase enzyme plays a role in the hydrolysis of carbohydrates into glucose in the intestine. Jombang leaves are a plant material that has the potential to be an antidiabetic. This research was an experimental study with samples of jombang leaf extract in 50% and 96% ethanol solvents. Alpha-glucosidase enzyme inhibition activity was tested in vitro using the colorimetric method. Jombang leaf extract with 50% ethanol solvent showed better alpha-glucosidase enzyme inhibition activity (IC50 25.399 ppm) compared to 96% ethanol solvent (IC50 319.107 ppm). The difference in the percentage inhibition of the alpha-glucosidase enzyme from the use of the two solvents showed no significant difference (Sig.>0,05).
| Item Type: | Thesis (Skripsi) |
|---|---|
| Additional Information: | Nuhaa: 1910212016 Pembimbing 1: Annisa Farida Muti Pembimbing 2: Eldiza Puji Rahmi Penguji 1: Dhigna Luthfiyani C.P |
| Uncontrolled Keywords: | alpha-glucosidase, antidiabetic, diabetes melitus, jombang leaves |
| Subjects: | R Medicine > R Medicine (General) R Medicine > RM Therapeutics. Pharmacology |
| Divisions: | Fakultas Kedokteran > Program Studi Farmasi (S1) |
| Depositing User: | Nuhaa Zuhdiyyah |
| Date Deposited: | 06 Sep 2023 09:04 |
| Last Modified: | 06 Sep 2023 09:04 |
| URI: | http://repository.upnvj.ac.id/id/eprint/25274 |
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