PENGARUH PEMBERIAN BIJI MARKISA KUNING (PASSIFLORA EDULIS VAR. FLAVICARPA) TERHADAP KADAR MDA TIKUS GALUR WISTAR DIABETIK

Indi Rafli Putra, . (2022) PENGARUH PEMBERIAN BIJI MARKISA KUNING (PASSIFLORA EDULIS VAR. FLAVICARPA) TERHADAP KADAR MDA TIKUS GALUR WISTAR DIABETIK. Skripsi thesis, Universitas Pembangunan Nasional Veteran Jakarta.

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Abstract

Diabetes mellitus (DM) is a chronic condition when blood glucose levels increase (hyperglycemia) because the body is unable to produce enough insulin or lack of effective insulin function. Hyperglycemia produces free radicals that induce lipid peroxidation with increasing Malondialdehyde (MDA) as a parameter of oxidative stress. Yellow passion fruit seeds (Passiflora edulis var. flavicarpa) contain flavonoids that can function as antioxidants in preventing tissue damage. The purpose of this study was to determine the effect of giving yellow passion fruit seeds on MDA levels of diabetic Wistar rats. This research is a true experimental with post test only control group design. Samples of male Wistar rats, aged 2-3 months, weighing 150-200 g, totaling 30 rats, were divided into 6 groups. Group 1 was given standard feed and drink (Normal Control), group 2 was given alloxan 125 mg/kgBW (Negative Control), group 3 was given alloxan and glibenclamide 0.45 mg/kgBW (Positive Control), groups 4, 5, and 6 were given alloxan and yellow passion fruit seeds (100, 200, and 400) mg/kgBW. The treatment was given for 14 days, then the rats were anesthetized with ketamine xylazine, and dissected, the blood was collected in an EDTA tube, centrifuged to separate the plasma in the Wills MDA examination method using a spectrophotometer with a wavelength of 532 nm. The results of the One Way ANOVA test showed that there was an effect of giving yellow passion fruit seeds on MDA levels (p = 0.000). The results of the Bonferroni test stated that there was no significant difference with the glibenclamide group (p = 1,000), meaning that 400 mg/kg BW yellow passion fruit seeds was the most effective dose in reducing MDA levels, which was almost the same as glibenclamide.

Item Type: Thesis (Skripsi)
Additional Information: [No.Panggil: 1810211016] [Pembimbing 1: Kristina Simanjuntak] [Pembimbing 1: Mila Citrawati] [Penguji 1: Maria Selvester Thadeus]
Uncontrolled Keywords: Diabetes mellitus; free radical; yellow passion fruit seeds; MDA
Subjects: R Medicine > R Medicine (General)
Divisions: Fakultas Kedokteran > Program Studi Kedokteran (S1)
Depositing User: Indi Rafli Putra
Date Deposited: 01 Mar 2023 06:51
Last Modified: 01 Mar 2023 06:51
URI: http://repository.upnvj.ac.id/id/eprint/23377

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