Astrid Devina Larasati, . (2023) HUBUNGAN KADAR SERUM ALP DAN KADAR SERUM LDH DENGAN GAMBARAN HISTOPATOLOGI OSTEOSARKOMA DI RSPAD GATOT SOEBROTO PADA PERIODE JANUARI 2016 – SEPTEMBER 2022. Skripsi thesis, Universitas Pembangunan Nasional Veteran Jakarta.
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Abstract
Background: Osteosarcoma is one of the most common non-hemopoietic primary bone cancers. Alkaline phosphatase (ALP) is an enzyme that is abundant in osteoblasts and plays a role in the mineralization mechanism of bone formation. In cases of osteosarcoma, ALP will experience an increase due to a high increase in osteoblastic activity. Lactate dehydrogenase (LDH) is an enzyme that functions in the anaerobic metabolic pathway. In cancer cells, LDH levels have increased because LDH function is modified to increase energy production. The purpose of this study was to determine the relationship between ALP serum levels and LDH serum levels before biopsy with histopathological features in osteosarcoma patients. Methods: This study is a cross-sectional retrospective study conducted at Gatot Soebroto Army Hospital, Jakarta. Data from osteosarcoma patients’ medical records were collected from January 2016 to September 2022. Then the data was processed using the chi-square test and logistic regression test. Results: The total sample of the study was 27 patients, and the p-value of ALP with histopathological features was 0.034, OR ALP and histopathological type was 14.793, OR ALP and histopathological grading was 5.867. LDH p-value and histopathological type was 0.239 and LDH p-value and histopathological grading was 0.452). Conclusion: There is a relationship between serum ALP levels and the histopathological features of osteosarcoma, with details of increased serum ALP levels increasing the risk of finding conventional histopathological type osteosarcoma by 14 times and increasing serum ALP levels increasing the risk of finding osteosarcoma with a high degree of malignancy by 5 times. There is no relationship between LDH serum levels and the histopathological features of osteosarcoma. Keywords: osteosarcoma, histopathological type, degree of malignancy, alkaline phosphatase serum, lactate dehydrogenase serum
| Item Type: | Thesis (Skripsi) |
|---|---|
| Additional Information: | [No. Panggil: 1910211076] [Pembimbing 1: Niniek Hardini] [Pembimbing 2: Basuki Supartono] [Penguji: Mila Citrawati] |
| Uncontrolled Keywords: | osteosarcoma, histopathological type, degree of malignancy, alkaline phosphatase serum, lactate dehydrogenase serum |
| Subjects: | R Medicine > R Medicine (General) R Medicine > RB Pathology R Medicine > RZ Other systems of medicine |
| Divisions: | Fakultas Kedokteran > Program Studi Kedokteran (S1) |
| Depositing User: | Astrid Devina Larasati |
| Date Deposited: | 07 Mar 2023 03:21 |
| Last Modified: | 07 Mar 2023 03:21 |
| URI: | http://repository.upnvj.ac.id/id/eprint/22330 |
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