Ovelia Yolanda, . (2020) PENGARUH APLIKASI TOPIKAL MADU, GEL Aloe vera, DAN MOIST EXPOSED BURN OINTMENT TERHADAP KEPADATAN KOLAGEN PADA PROSES PENYEMBUHANLUKA BAKAR DERAJAT II TIKUS (Rattus norvegicus). Skripsi thesis, Universitas Pembangunan Nasional Veteran Jakarta.
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Abstract
Various scientific studies have proven that collagen is an ideal biomaterial in wound healing activities. Several bioactive compounds have been identified in honey, Aloe vera, and Moist Exposed Burn Ointment (MEBO) which contributed to increase collagen formation. The present study was conducted to compare the effect of topical application of honey, Aloe vera gel, and MEBO to collagen density in the healing process of second-degree burn wounds in rat. Twenty-eightmale Wistar rats were randomly selected and divided into four groups: NaCl,honey, gel Aloe vera, and MEBO. The second-degree burns were made on the rat’s posterior surface using an electric solder. Each group was treated topically, twice a day for six consecutive days. Skin biopsies were conducted on the seventh days, then stained using Hematoxylin eosin and the collagen density wascalculated. One Way Anova test showed that the collagen density was significantlydifferent between groups respectively (p=0,009). Post Hoc Multiple Comparison Bonferroni test showed that there were statistically significant differences between NaCl with honey (p=0,024) and NaCl with MEBO group (p=0,024). Thispresent study indicate that topical application of honey and MEBO on the seconddegree burns can increasing collagen formation, thus it can accelerate woundhealing process.
| Item Type: | Thesis (Skripsi) |
|---|---|
| Additional Information: | [No Panggil : 1610211021] [Pembimbing : Sekar Dorojati Yuliana] [Penguji : Yudhi Nugraha] |
| Uncontrolled Keywords: | Burn, collagen, honey, Aloe vera, MEBO |
| Subjects: | R Medicine > R Medicine (General) R Medicine > RM Therapeutics. Pharmacology |
| Divisions: | Fakultas Kedokteran > Program Studi Kedokteran (S1) |
| Depositing User: | Deny Wahyudin |
| Date Deposited: | 23 Jun 2022 02:46 |
| Last Modified: | 23 Jun 2022 02:46 |
| URI: | http://repository.upnvj.ac.id/id/eprint/18078 |
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