PENGARUH PENGGUNAAN ANTIKOAGULAN TERHADAP MORTALITAS PASIEN COVID-19 DENGAN RISIKO KOAGULOPATI: Systematic Review

Sapphira Mazaya Salsabila, . (2022) PENGARUH PENGGUNAAN ANTIKOAGULAN TERHADAP MORTALITAS PASIEN COVID-19 DENGAN RISIKO KOAGULOPATI: Systematic Review. Skripsi thesis, Universitas Pembangunan Nasional Veteran Jakarta.

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Abstract

Background: One of the most common cause of death in hospitalized COVID-19 patients is related with the progression of coagulopathy that caused by hyperinflammatory events thus causing a systemic cytokine storm resulting systemic inflammatory response syndrome (SIRS). In COVID-19 guideline of treatment by Indonesian Association of Pulmonary, Cardiovascular, and Internal Medicine Physicians recommends the use of anticoagulants in all hospitalized COVID-19 patient adjusted with appropriate clinical judgement. This systematic review was conducted to analyze the effect of anticoagulants use on mortality in COVID-19 patients who at risk of coagulopathy. Methods: A systematic review conducted by starting a literature search from May to July 2021. The literature that being analyzed was from Google Scholar, PubMed, EBSCO, and Science Direct database using PRISMA-P 2020. Results: Datas were obtained from nine journals. Eight of them stated that the use of prophylactic and therapeutic doses, has an effect on reducing the mortality rate of COVID-19 patients and one journal did not see a significant difference on mortality of COVID-19 patients. Types of anticoagulant that are widely used in nine journals are heparin and fondaparinux with doses adjusted to coagulation marker. Conclusion:The use of anticoagulant is beneficial in reducing mortality rates in hospitalized COVID-19 patients.

Item Type: Thesis (Skripsi)
Additional Information: [No. Panggil: 1810211048] [Pembimbing 1: Hany Yusmaini] [Pembimbing 2: Feda Anisah Makiyah] [Penguji 1: Mila Citrawati]
Uncontrolled Keywords: Anticoagulant, coagulopathy, COVID-19, mortality
Subjects: R Medicine > R Medicine (General)
R Medicine > RC Internal medicine
R Medicine > RM Therapeutics. Pharmacology
Divisions: Fakultas Kedokteran > Program Studi Kedokteran (S1)
Depositing User: Sapphira Mazaya Salsabila
Date Deposited: 11 Feb 2022 06:36
Last Modified: 11 Feb 2022 06:36
URI: http://repository.upnvj.ac.id/id/eprint/16307

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