EFIKASI PENGGUNAAN SENYAWA KURKUMIN DALAM EKSTRAK Curcuma longa L. SEBAGAI TERAPI ALTERNATIF GANGGUAN DEPRESI: Systematic Review

Nabilah Nurul Fitri, . (2021) EFIKASI PENGGUNAAN SENYAWA KURKUMIN DALAM EKSTRAK Curcuma longa L. SEBAGAI TERAPI ALTERNATIF GANGGUAN DEPRESI: Systematic Review. Skripsi thesis, Universitas Pembangunan Nasional Veteran Jakarta.

[img] Text
ABSTRAK.pdf
Download (332kB)
[img] Text
AWAL.pdf
Download (2MB)
[img] Text
BAB 1.pdf
Download (108kB)
[img] Text
BAB 2.pdf
Restricted to Repository UPNVJ Only
Download (249kB)
[img] Text
BAB 3.pdf
Restricted to Repository UPNVJ Only
Download (177kB)
[img] Text
BAB 4.pdf
Restricted to Repository UPNVJ Only
Download (286kB)
[img] Text
BAB 5.pdf
Download (84kB)
[img] Text
DAFTAR PUSTAKA.pdf
Download (5MB)
[img] Text
RIWAYAT HIDUP.pdf
Restricted to Repository UPNVJ Only
Download (283kB)
[img] Text
LAMPIRAN.pdf
Restricted to Repository UPNVJ Only
Download (5MB)
[img] Text
HASIL PLAGIARISME.pdf
Restricted to Repository staff only
Download (11MB)
[img] Text
ARTIKEL KI.pdf
Restricted to Repository staff only
Download (608kB)

Abstract

Depression is a psychiatric disorder with a prevalence rate that increased to 57.6% during the COVID-19 pandemic. One alternative therapy that has been researched and assessed to have various effects in reducing symptoms of depression is the compound curcumin in Curcuma longa L extract. This study aims to determine the efficacy of using curcumin compounds in Curcuma longa L extract as an alternative therapy for depression. This research design uses a systematic review. The literature search in this systematic review was carried out on four different journal databases, namely PubMed, Prime Pubmed, ScienceDirect, and EBSCO using the 2015 PRISMA-P method covering articles from March to May 2021. There were twenty studies that met the research inclusion and exclusion criteria. . The results showed that curcumin at a dose of 100 mg/kg in in vivo trials and 250 mg in clinical trials had significant efficacy and potential as an alternative therapy in depressive disorders. This curcumin compound provides significant changes in improving depression-like behavior in rats through modulating neurotransmitter effects, reducing proinflammatory cytokines, increasing BDNF, reducing cortisol levels, and curcumin being able to improve depressive disorders in patients in clinical trials.

Item Type: Thesis (Skripsi)
Additional Information: [No. Panggil: 1810211077] [Pembimbing 1: Via Rifkia] [Pembimbing 2: Boenga Nurcita] [Penguji: Hany Yusmaini]
Uncontrolled Keywords: Curcumin, Curcuma longa L, Depression-like behavior, Depressive Disorders, Antidepressant.
Subjects: R Medicine > RS Pharmacy and materia medica
Divisions: Fakultas Kedokteran > Program Studi Kedokteran (S1)
Depositing User: Nabilah Nurul Fitri
Date Deposited: 04 Mar 2022 06:30
Last Modified: 04 Mar 2022 06:30
URI: http://repository.upnvj.ac.id/id/eprint/16218

Actions (login required)

View Item View Item